Synthesis of cationic quaternized pullulan derivatives for miRNA delivery
نویسندگان
چکیده
منابع مشابه
Synthesis and antitubercular activity of quaternized promazine and promethazine derivatives.
Quaternized chlorpromazine, triflupromazine, and promethazine derivatives were synthesized and examined as antitubercular agents against both actively growing and non-replicating Mycobacterium tuberculosis H37Rv. Impressively, several compounds inhibited non-replicating M. tuberculosis at concentrations equal to or double their MICs against the actively growing strain. All active compounds were...
متن کاملZero birefringence films of pullulan ester derivatives
High-performance films with almost zero-birefringence and zero-wavelength dispersion were succeeded to prepare from pullulan esters derivatives (PLEs) without any additives. Optical transmittance analysis, birefringence measurement of PLE cast film and hot stretched films, and infrared dichroism analysis were conducted to characterize optical properties of PLE films comparing with cellulose tri...
متن کاملFunctionalization of Cellulose: Synthesis of Water-soluble Cationic Cellulose Derivatives
One of the trends of modern cellulose chemistry is the functionalization of known cellulose derivatives in order to expand their application area. In this work, water-soluble cationic cellulose derivatives containing up to 4% coupled nitrogen were obtained by the amination of hydroxyethylcellulose (HEC) with two different etherification agents, diethylepoxypropylamine (DEEPA) and (2-chlorethyl)...
متن کاملSynthesis of cationic polysaccharide derivatives and their hypocholesterolaemic capacity.
High-capacity bile acid-sequestering biopolymers with cationic polysaccharide derivatives have been developed. Cholestyramine, the bile acid sequestrant most widely used for treating hypercholesterolaemia, has unpleasant side effects because of the hydrophobic nature of its backbone. Methylan, a high-viscosity polysaccharide produced by Methylobacterium organophilum, was selected as a model pol...
متن کاملSynthesis and spectroscopic characterization of two tetrasubstituted cationic porphyrin derivatives.
An imidazolium tetrasubstituted cationic porphyrin derivative (the free base and its Zn(II) complex) with five-membered heterocyclic groups in the meso-positions were synthesized using microwave irradiation, and the compounds obtained characterized by (1)H-NMR and mass spectrometry. We observed that under microwave irradiation the yield is similar to when the synthesis is performed under conven...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Pharmaceutics
سال: 2020
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2020.119041